Polenoplasmin pentru vindecarea paraliziiei la caini a fost invitat la Boston la conferinta 5th annual Microbiome Connect: Animal,

Hi Gheorghe Giurgiu,  Are you looking to apply metagenomic sequencing techniques to assist in the development effective of microbiome-modulating feeds and supplements?  At the 5th annual Microbiome Connect: Animal, we'll be discussing the latest research and developments around these cutting-edge technologies. Join us in Boston on June 21-22 for a series of dedicated sessions tailored to improve your understanding of microbiome sequencing and how it can vastly improve your ability to develop functional, effective products targeting the animal microbiome.  To save up to $900 on your ticket, book your place today and take advantage of our super early bird pricing ending next week, March 4!    with actionable takeaways including: Learn about the role of key microbes in gut health, and adopt strategies that help you to target these microbes to transform your microbiome product development with Itzhak Mizrahi, Professor, Ben-Gurion University of the Negev Develop products that efficiently target key members of the microbiome by using sequencing techniques to better understand and categorise host-microbe interactions with John Parkinson, Senior Scientist - Molecular Medicine, University of Toronto Improve your understanding of the complex interactions between pathogens and the microbiome, and how to alter them to produce products that lead to positive animal health outcomes with Alain Labbé, Director of Research, Microsintesis To remind yourself of the full range of sessions on offer view the agenda here, don't worry, there's no form attached!  This year, Microbiome Connect: Animal is in collaboration with Animal Health, Nutrition & Technology Innovation USA, taking place June 21-23 in Boston. Upgrade your ticket at checkout for a small fee that allows you to visit both shows!  Do let me know if you have any questions.  Best wishes,  Ethan Walton Conference Producer | Kisaco Research Microbiome Connect: Animal    Kisaco Research, 41a Maltby Street, London, Greater London SE1 3PA, United Kingdom, 02036962920 Unsubscribe Manage preferences

Gut dysbiosis in dogs with spinal cord injury: Impact of Polenoplasmin

Major Giurgiu Gheorghe¹

¹Deniplant-Aide Sante Medical Center, Biomedicine, Bucharest, Romania

deniplant@gmail.com; Telephone: +40744827881

https://orcid.org/0000-0002-5449-2712

Prof. dr. Cojocaru Manole²

²Titu Maiorescu University, Faculty of Medicine, Bucharest, Romania

cojocaru.manole@gmail.com; Telephone: +40723326663
https://orcid.org/0000-0002-6871-577X

 

Background Studies have demonstrated the presence of gut dysbiosis (alterations in gut bacterial homeostasis) secondary to spinal cord injury in dogs. The dysbiosis is thought to impair recovery by decreasing the production of short-chain fatty acids which play a role in suppressing inflammation within the central nervous system.  

Obiective Therefore, targeting gut dysbiosis could have significant therapeutic value in the management of spinal cord injury. The purpose of this study is to determine if gut dysbiosis occurs in dogs with spinal cord injury. Another area of potential intervention interest is in situations of spinal injury where there is an urgent need to generate new neurons. To arrive at these observations, the authors examined how Polenoplasmin and diet solve paralysis in dogs. 

Materials and methods The most common cause of spinal problems in dogs is trauma. We are currently assessing whether indoles can also stimulate formation of neurons in dogs with paralysis.

Results We found that gut microbes that metabolize tryptophan-an essential amino acid-secrete small molecules called indoles, which stimulate the development of new brain cells in dogs, also demonstrated that the indole-mediated signals elicit key regulatory factors known to be important for the formation of new neurons.

Conclusion This study is another intriguing piece of the puzzle highlighting the importance of lifestyle factors and diet.

In conclusion, the link between the health of the microbiome and the health of the brain shows how microorganisms in the gut solve paralysis. Gut microbe secreted molecule linked to formation of new nerve cells in paralysed dogs.

Keywords: intestinal dysbiosis, indoles, paralysed dog, Polenoplasmin.