Academy of Romanian Scientists
Annals Series on Biological Sciences
Copyright ©2020 Academy of Romanian Scientists
Volume 9, No. 1, 2020, pp. 88- 96
ISSN 2285 – 4177
ORIGINAL PAPERS
Academy of Romanian Scientists Annals - Series on Biological Sciences, Vol. 9, No.1, (2020) 88
The Role of Intestinal Microbiote
in Neuromuscular Diseases in Paralized Dogs
Gheorghe GIURGIU1*, Manole COJOCARU2
1Deniplant-Aide Sante Medical Center, Biomedicine, Bucharest, 012371, Romania
2Titu Maiorescu University, Faculty of Medicine, Bucharest, 031593, Romania
* Corresponding author e-mail: deniplant@gmail.com
Abstract
In order to be able to move, animals like man need the nervous and muscular
system to function optimally. The brain, spine, nerves and muscles must work
together. If there is a disturbance, the messages will not reach the destination and
the animal will not be able to move. Depending on the location and extent of the
neurological lesions, the dog may paralyze in whole or in part. Post-traumatic
paralysis is a complex condition that requires proper treatment and thorough
investigations to establish an accurate diagnosis. There are several conditions that
can cause paralysis in the dog. The interaction between the health of the
microbiome and that of the brain as well as the way it communicates immune and
neuronal cells has been studied. Intestinal cells affect the cells of the central
nervous system in the brain. The intestinal-brain axis may influence different
neurological disorders and it is possible that dysbiosis in the intestinal tract may
lead to disturbance of the transmission of nerve controls on the neuromuscular
plate. By-products of microorganisms in the intestine, which appear as a result of
tryptophan processing in the diet, can limit the level of inflammation in the brain
by the influence they have on microglial cells. The current research focuses on the
influence that the gut microbiota has on microglial cells and astrocytes that play
an important role in the health of the central nervous system. To reach these
observations, the authors examined how intestinal microbiota and diet influence
amelioration of paralysis in dogs. In conclusion, the link between the health of the
microbiome and the health of the brain, shows how the microorganisms in the
intestine influence the evolution of paralysis.
Keywords: microbiome, intestinal dysbiosis, neuroimmunomodulation, paralysis,
dog.
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